Indole Hexaphosphate (IP6)- Mechanism of action

“When you arise in the morning, think of what a precious privilege it is to be alive - to breathe, to think, to enjoy, and to love.” - Marcus Aurelius

Hello Zuncia Family,

Today’s post is about the mechanism involved in inhibition of cancer by Indole Hexaphosphate (IP6) and inositol. In our earlier posts, we shared research and people’s stories about role of IP6 on various kinds of cancer.

Cancer is growing rapidly worldwide in terms of incidence as well as mortality. According to World Health Organisation (WHO), American Cancer Society and other organisations, cancer cases is projected to grow to 24 million and over millions deaths annually by 2050. However, the cases are growing rapidly after COVID pandemic, more than projected here. Despite so much efforts and spending on research, cancer remains still a challenge for global public health.

To reduce burden of cancer, cancer prevention by use of non-toxic naturally occurring compounds is a good strategy for management of cancer. Let’s dive in.

IP6 is one of the naturally occurring compound with anti-cancer properties. It is the most abundance polyphosphate in nature. It is found in rice, wheat, barley, oats, beans and peas in concentrations ranging from 0.4- 6.4 %. It is also known as phytic acid. And it’s parent compound my-inositol is naturally present in plant and animal cells. The presence of phosphate group in unique positions (1, 2, 3) in the structure of IP6 give unique characteristics to this molecules, such as antioxidant and specific chelating capacity of toxic chemicals.

Mechanism of Action

Animal and plant cells contain Inositol either in free form, as inositol containing phopholipids or as IP6 (phytic acid). And all plant and animal cells contain high concentration of IP6, Inositol and other inositol phopholipids. These compounds play an important role in vital cellular functions-

• Signal Transduction

• Regulation of Cell proliferation and differentiation

• RNA export

• mRNA transcription

• DNA repair

• Energy transduction

• ATP generation

And de-regulation of there metabolism has been reported in many diseases, neurological disorders, Polycystic Ovarian Syndrome (PCOS), metabolic diseases and Cancer.

The preventive and therapeutic effect of IP6 is depend upon its antioxidant functions, ability to block the activity of various carcinogens or to stimulate their detoxification, to immune enhancing anti-inflammatory activities and to the suppression of cell cycle and proliferation . The induction of differentiation and apoptosis in various premalignant and cancareous cells can also contribute to both preventive and therapeutic potential of IP6. IP6 work at molecular level via P13k, MAPK, PKC, AP-1 and NF-kappaB.

The research article discussed in this post is https://www.jstage.jst.go.jp/article/jnsv/65/Supplement/65_S18/_pdf/-char/en

All the references are given in this article.

Today’s Mantra: I am Happy and Healthy.

With much love,

Sudesh

Founder, zuncia.com